4-benzyl-1-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
1,4-Piperidinedicarboxylic acid, 4-(phenylmethyl)-, 1-(1,1-dimethylethyl)ester
CAS: 167263-11-8
Molecular Formula: C18H25NO4
4-benzyl-1-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid - Names and Identifiers
4-benzyl-1-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C18H25NO4 |
| Molar Mass | 319.4 |
| Density | 1.167±0.06 g/cm3(Predicted) |
| Boling Point | 456.9±38.0 °C(Predicted) |
| pKa | 4.44±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Irritant |
| MDL | MFCD02179131 |
4-benzyl-1-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid - Introduction
1,4-piperidinedicarboxylic acid, 4-(phenylmethyl)-, 1-(1,1-dimethylethyl)ester is an organic compound whose chemical name is tert-butyl. Its properties are as follows:
Nature:
Appearance: Colorless to light yellow solid
Molecular formula: C19H27N3O2
Relative molecular mass: 341.44g/mol
Melting point: 89-92 ℃
Boiling point: 475.6 ℃
Solubility: Soluble in common organic solvents.
Use:
1,4-piperidinedicarboxylic acid, 4-(phenylmethyl)-, 1-(1,1-dimethylethyl)ester is a commonly used protective reagent in organic synthesis. Boc Group Protection The amine group can be protected during synthesis from unintended reactions such as acylation and reduction. In addition, it can also be used as an intermediate for the synthesis of compounds with pharmaceutical activity.
Method:
1,4-piperidinedicarboxylic acid, 4-(phenylmethyl)-, 1-(1,1-dimethylethyl)ester can be obtained by N-alkylation of piperidine. The specific preparation steps are as follows:
1. Dissolve piperidine in dichloromethane
2. Add benzyl bromide and potassium carbonate to react
3. Add Boc-dehydrating agent for dehydration reaction
4. Distillation purification to obtain the target product.
Safety Information:
1,4-piperidinedicarboxylic acid, 4-(phenylmethyl)-, 1-(1,1-dimethylethyl)ester is generally relatively safe under normal operating conditions, but still need to pay attention to the following matters:
-Avoid contact with skin, eyes and respiratory tract, and avoid inhaling dust or vapor.
-Use suitable protective gloves, goggles and respiratory protection equipment during operation.
-Operate in a well-ventilated place and avoid contact with oxidants and strong acids.
-Keep it sealed when stored and keep it away from open flames and high temperatures.
-In the event of accidental ingestion or exposure, seek medical help immediately and show your product safety data sheet to your doctor.
Please note that this information is for reference only. Please refer to the safety data sheet and operating procedures of the product for specific operation and use, and operate under the guidance of experienced personnel.
Nature:
Appearance: Colorless to light yellow solid
Molecular formula: C19H27N3O2
Relative molecular mass: 341.44g/mol
Melting point: 89-92 ℃
Boiling point: 475.6 ℃
Solubility: Soluble in common organic solvents.
Use:
1,4-piperidinedicarboxylic acid, 4-(phenylmethyl)-, 1-(1,1-dimethylethyl)ester is a commonly used protective reagent in organic synthesis. Boc Group Protection The amine group can be protected during synthesis from unintended reactions such as acylation and reduction. In addition, it can also be used as an intermediate for the synthesis of compounds with pharmaceutical activity.
Method:
1,4-piperidinedicarboxylic acid, 4-(phenylmethyl)-, 1-(1,1-dimethylethyl)ester can be obtained by N-alkylation of piperidine. The specific preparation steps are as follows:
1. Dissolve piperidine in dichloromethane
2. Add benzyl bromide and potassium carbonate to react
3. Add Boc-dehydrating agent for dehydration reaction
4. Distillation purification to obtain the target product.
Safety Information:
1,4-piperidinedicarboxylic acid, 4-(phenylmethyl)-, 1-(1,1-dimethylethyl)ester is generally relatively safe under normal operating conditions, but still need to pay attention to the following matters:
-Avoid contact with skin, eyes and respiratory tract, and avoid inhaling dust or vapor.
-Use suitable protective gloves, goggles and respiratory protection equipment during operation.
-Operate in a well-ventilated place and avoid contact with oxidants and strong acids.
-Keep it sealed when stored and keep it away from open flames and high temperatures.
-In the event of accidental ingestion or exposure, seek medical help immediately and show your product safety data sheet to your doctor.
Please note that this information is for reference only. Please refer to the safety data sheet and operating procedures of the product for specific operation and use, and operate under the guidance of experienced personnel.
Last Update：2024-04-09 19:05:47
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